Effects of SLCO1B1 polymorphism on the pharmacokinetics of the oral antidiabetic drugs repaglinide, nateglinide, rosiglitazone, and pioglitazone
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Bioequivalence Evaluation of a Combine Formulation of Pioglitazone/ Metformin in Healthy Pakistani Volunteers
Numerous oral antidiabetic drugs with different mechanisms of action have been developed to lower glucose and delay the occurrence of serious complications in patients with type 2diabetes [1]. For glycemic control in diabetic patients, monotherapy with an oral antidiabetic agent is not adequate to achieve satisfactory blood glucose control [2]. Thus, combination regimens which include drugs wit...
متن کاملSeparation and Quantification of Eight Antidiabetic Drugs on A High-Performance Liquid Chromatography: Its Application to Human Plasma Assay
An analytical method based on isocratic reverse phase high-performance liquid chromatography was developed and validated for the separation and quantification of eight antidiabetic drugs: rosiglitazone, pioglitazone, glipizide, gliclazide, repaglinide, nateglinide, glibenclamide, and glimepiride for their application in human plasma assay. Metformin is used as internal standard. Analysis was do...
متن کاملPrediction of the metabolic interaction of nateglinide with other drugs based on in vitro studies.
Nateglinide is an antidiabetic agent metabolized by CYP2C9 and CYP3A4; hence inhibitors of these CYP isozymes may interact with nateglinide. There are, however, only limited in vitro data on how to predict drug-drug interactions in vivo. We examined the effects of 18 drugs that may be prescribed together with nateglinide (metformin, buformin, aspirin, gemfibrozil, simvastatin, pioglitazone, ros...
متن کاملInteraction of oral antidiabetic drugs with hepatic uptake transporters: focus on organic anion transporting polypeptides and organic cation transporter 1.
OBJECTIVE The uptake of drugs into hepatocytes is a key determinant for hepatic metabolism, intrahepatic action, their subsequent systemic plasma concentrations, and extrahepatic actions. In vitro and in vivo studies indicate that many drugs used for treatment of cardiovascular diseases (e.g., oral antidiabetic drugs, statins) are taken up into hepatocytes by distinct organic anion transporters...
متن کاملPlasma pharmacokinetics of pioglitazone following oral or intravenous administration in Holstein cows
Pioglitazone belongs to the thiazolidinedione (TZD) class of antidiabetic agents, with proven efficacy in increasing insulin sensitivity and in the treatment of type 2 diabetes mellitus in humans. Pioglitazone has been proposed as a potential feed additive to reduce insulin resistance and consequently some of the metabolic disorders in transition cows. This study was aimed at determining the ph...
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تاریخ انتشار 2008